Part:BBa_K3712001
Bombinin-like peptide 7 (BLP-7)
Bombinin-like peptide 7 (BLP-7), which was determined from Bombina orientalis, has been shown to possess certain antibacterial activity. Study shows that 5μM of it inhibits P. acnes’ growth in vitro. It is an antimicrobial peptide consisting of 27 amino acids and has been shown to have a broad spectrum of antibacterial activity. Cell experiments showed that BLP-7 inhibits the expression of two proinflammatory cytokines IL-8 and granulocyt-macrophage colony-stimulating factor (GM-CSF) in normal human epidermal keratinocytes (NHEKs), and had anti-inflammatory effects. The secondary structure of BLP-7 is a cationic amphiphilic α helix, which can target the lipid bilayer of bacterial cell plasma membrane, punch holes through the membrane and kill bacteria. Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal PstI site found at 26
- 12INCOMPATIBLE WITH RFC[12]Illegal PstI site found at 26
- 21COMPATIBLE WITH RFC[21]
- 23INCOMPATIBLE WITH RFC[23]Illegal PstI site found at 26
- 25INCOMPATIBLE WITH RFC[25]Illegal PstI site found at 26
- 1000COMPATIBLE WITH RFC[1000]
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